Copyright © 2021 Bakker, Mol, Nabais, Vetter, Kretzler, Nolan, Mayer, Sundgren, Heerspink, Schiel, de Vries, Gomez, Schulze, de Zeeuw and Pena.
Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building
As part of an ongoing effort of moving implementation of precision medicine in DKD forward, a two-day consensus-building meeting was organized with different stakeholders involved in drug development and patient care in DKD, including patients, patient representatives, pharmaceutical industry, regulatory agencies representatives, health technology assessors, healthcare professionals, basic scientists, and clinical academic researchers. The study summarizes their views with regards to benefits and obstacles of implementing precision medicine in diabetic kidney disease (DKD) and discusses how to build consensus about a way forward to treat, prevent, or even reverse this disease.
Link to the paper:
https://pubmed.ncbi.nlm.nih.gov/34025424/
Published in:
Frontiers in Pharmacology
5th BEAt-DKD annual plenary meeting
Scientists of the BEAt-DKD consortium and members of our strategic Advisory Board convened for the Annual Plenary meeting at the Nicolaus Hotel in Bari, Italy on 2-4 May 2022, with additional 30 scientists participating remotely. Five years into the project, work packages presented exciting new data and overall great progress. Next Plenary meeting will be organized in June 2023, by the academic lead Lund University, in Malmö. Sweden.
iBEAT protocol paper will be published
iBEAt PROTOCOL PAPER ACCEPTED IN BMC NEPHROLOGY AND AVAILABLE AT medRXiv
iBEAt is a prospective multi-centre observational cohort study recruiting 500 patients with type 2 diabetes (T2D) and eGFR > 30ml/min/1.73m2. Being the largest DKD imaging study to date, iBEAt will provide invaluable insights into the progression and heterogeneity of DKD, and aims to contribute to a more personalized approach to the management of DKD in patients with type 2 diabetes.
https://www.medrxiv.org/content/10.1101/2020.01.13.20017228v1
Control podocytes
GSK3 knockout podocytes
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
Preclinical studies show that the enzyme Glycogen Synthase Kinase 3 (GSK3) is a critical regulator of cellular function in podocytes and nephrocytes. Mechanistically GSK3 is important for maintaining the differentiated phenotype of these cells and preventing them from re-entering the cell cycle resulting in apoptosis through mitotic catastrophe.
www.doi.org/10.1038/s41467-018-08235-1
Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease
In this study it was shown for the first time that decreased expression of the renoprotective factor dicarbonyl and L-xylulose reductase (DCXR) is associated with human chronic kidney disease (CKD) progression. DCXR is mainly expressed in renal proximal tubuli and DCXR expression was also significantly reduced in CKD as compared to healthy controls. Due to its mechanistic link to the degradation of dicarbonyl compounds, DCXR depicts a novel target in CKD.
doi.org/10.1172/jci.insight.128120
2nd Symposium on Precision Medicine in Diabetic Kidney Disease – Stakeholders´Perspectives: Amsterdam, Netherlands, 3-4 April 2019
The goal of this symposium is to reach a consensus on how to move Precision Medicine into daily clinical practice of treating diabetes. We think that this will only happen if we can align stakeholder opinions and goals. Therefore, this symposium invites stakeholders from patient organizations, physician groups, drug regulators, health technology assessors, academia, and industry to participate in brainstorming and discussion. This meeting is part of WP6, the IMI2 BEAT-DKD project.
For more information on the symposium:
2nd BEAt-DKD annual plenary meeting
More than 80 scientists of the BEAt-DKD consortium and members of our strategic Advisory Board convened for the Annual Plenary meeting at the Biomedicum in Helsinki, Finland on 15-16 October 2018. Two years into the project, work packages presented exciting new data and overall great progress. Next Plenary meeting will be organized on 15-16 October 2019, by the academic co-lead University Medical Center Groningen, the Netherlands.
Supplement of the journal Diabetes, Obesity & Metabolism
BEAt-DKD aims to foster personalized medicine for diabetic kidney disease. Personalized pharmacotherapy requires an integrated effort of many stakeholders including healthcare providers, the academic community, the pharmaceutical industry, trial designers, health policy makers, regulatory authorities, insurance companies, doctors, patients and the general public. Early engagement of these stakeholders is important as they may have different priorities. BEAt-DKD participants organized a conference on personalized medicine in diabetic kidney disease in December 2017 in Groningen, the Netherlands to discuss the state of the art, challenges and solutions for successful implementation of personalized medicine in diabetic kidney disease. A summary and main findings of this conference are now published in a dedicated supplement of the scientific journal Diabetes, Obesity & Metabolism.
Diabetes, Obesity & Metabolism, Volume 20, Issue S3.
Guest editor: Hiddo J. L. Heerspink
First BEAt-DKD Plenary meeting held in October 2017
One year after the start of BEAt-DKD on 1st September 2016, more than 60 scientists of the BEAt-DKD consortium convened for the first Plenum meeting in a pleasant and very positive atmosphere in Oberursel, Germany on 5-6 October 2017. During the assembly, kindly hosted by project co-leader Sanofi, the six project work packages presented already great progress and achievements for these first 12 months. The Plenary meeting also gave the opportunity for many of our researchers to meet in person for the first time and to explore joint research interests, while aligning our key research activities towards project year two.
We were very happy to welcome the members of our strategic Advisory Board, advising us on research strategies and focus points, which will further improve the smooth running and the achievement of future goals of the project.
Overall, the first annual meeting of the BEAt-DKD consortium, with a near complete representation from our 31 partners, resulted in a very fruitful meeting, leaving everyone feeling happy after 2 days of intensely working together towards the final goal of BEAt-DKD: to elucidate targetable mechanisms and pathways underlying the initiation and progression of DKD.
The second Plenary meeting will be organized by the academic co-lead University of Helsinki on 15-16 October 2018.
Boehringer-Ingelheim joins the BEAt-DKD consortium as new participant
As 7th EFPIA partner, Boehringer-Ingelheim has joined BEAt-DKD on 13 Nov 2017 to bring their expertise in research on diabetic kidney disease (DKD) into the consortium. Their comprehensive knowledge in research and development of compounds for the treatment of diabetes and cardio-vascular diseases will support the overall project goal to elucidate targetable mechanisms and pathways underlying the initiation and progression of DKD. Analytical assays and pre-clinical models provided by Boehringer-Ingelheim will complement technologies already available in the consortium for the identification and validation of biomarkers of disease progression and treatment response as a first step towards precision medicine of DKD.
