New KDIGO guidelines

New KDIGO guidelines for the evaluation and management of chronic kidney disease (CKD) have been published. We are witnessing a transformative era in nephrology, with increasingly sophisticated diagnostic tools and advances in technology, with better integration of the latest evidence and expert consensus, all of which will hopefully help catalyze a more coordinated CKD care management worldwide, ultimately improving outcomes for people with CKD.

We are pleased to see KidneyIntelX™ developed by PRIME-CKD partner Renalytix, included as a biomarker-based risk assessment tool (page 87, Table 20) for CKD progression.

Link to the guidelines


Regulatory support for the Multiple Parameter Drug Response score

The multiple parameter drug response score (PRE score) predicts the change in risk in reaching renal endpoints on the basis of the effects of a drug on multiple parameters involved in renal progression and protection. With this prediction, the PRE score intents to improve drug development and study design for registration trials in (diabetic) patients with chronic kidney disease. Various validation studies of the PRE score have been conducted, which have led the BEAt-DKD consortium members to reach out to the European Medicines Agency (EMA) for a so-called qualification opinion. This has resulted in a letter of support implying that the EMA supports the development effort towards intermediate and final validation of the PRE score as a tool for drug development in kidney diseases.

Link to the Letter of Support


Patient event

The iBEAt/BEAT-DKD study team is inviting its study participants to attend a patient event where the ideas behind the study will be discussed and iBEAt researchers can answer some of the questions that participants have been asking. During the event, a panel of experts will give short presentations on the various areas covered by the study, ending with a question-and-answer session.

The meeting will be held virtually or in person on Wednesday the 30th of August starting at 9 am and will last about 2.5 hours. All will be in English but live translation in Italian will be available.

Areas covered in this event:

  • What is the BEAt-DKD consortium? Why is it interested in diabetic kidney disease?
  • What is the iBEAt / BEAT-DKD study that you are participating in trying to achieve?
  • Why do I need to be in the MRI scanner for so long?
  • Why are you looking at the amount of fat and where it is, in my MRI images?
  • Why are you collecting so much of my blood and urine? What happens to it?
  • Why are participants in Bari, Italy also having a kidney biopsy? Why is this important?
  • What is the microvascular study? Why are we interested in the smallest blood vessels?
  • Why are big drug companies interested in being involved with the BEAt-DKD consortium?

The study team intends to record the event and a recording of each talk will be added to the BEAt-DKD website and will be available online after the event.

Link to agenda file


EV art by K. Barreiro: An electron micrograph of urinary extracellular vesicles that highlights extracellular vesicle subpopulations reflecting kidney derived vesicles carrying the stress score. (Image: Karina Barreiro)

The small extracellular vesicles in urine show transcriptomic stress signature in diabetic kidney disease

Genome-wide sequencing of mRNAs in urinary extracellular vesicles (EV) revealed a transcriptomic signature that associated with declining kidney function in diabetic kidney disease. The study included over 150 individuals with type 1 and type 2 diabetes from three different diabetes cohorts: FinnDiane, DIREVA, and iBEAt. The signature genes were involved in the management of oxidative and cellular stress and hence allowed calculation of an EV-based “stress score”. Significantly, the stress score proved to be higher in individuals showing an early declining trend of kidney function, but not yet albuminuria. The study additionally showed that EV and the stress signature in urine of the patients with diabetes are prominently coming from the kidney cortex and from proximal tubular cells. Thus, urine EV provide a potential “liquid kidney biopsy” and early non-invasive markers of developing kidney disease.

Link to the paper:
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

Published in:

Read more on the University of Helsinki’s webpage:
Stress markers in diabetic kidney disease exposed in urinary vesicles


BEAt-DKD symposium

Aligned with the final Consortium meeting, BEAt-DKD proudly presented research highlights and important take-home messages from 7 fruitful years of BEAt-DKD collaboration, by organising a public BEAt-DKD symposium: Successful stories, lessons learned and what’s next? on June 21,2023, in Malmö


Final BEAt-DKD annual Plenary meeting

For the last time as a consortium, BEAt-DKD scientists and members of our strategic Advisory Board met for the Annual Plenary meeting, this time at the Coordinator site at Lund University, Malmö, Sweden, on 19-20 June 2023. After almost 7 years, the project members had many exciting new data and overall great progress to present and discuss!

Press release news picture

UMCG Lead Collaborations to advance Precision Medicine in Chronic Kidney Disease

Consortium of Academic and Industry leaders will develop tests for monitoring of individual patients’ response to drug therapies.


Copyright © 2021 Bakker, Mol, Nabais, Vetter, Kretzler, Nolan, Mayer, Sundgren, Heerspink, Schiel, de Vries, Gomez, Schulze, de Zeeuw and Pena.

Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building

As part of an ongoing effort of moving implementation of precision medicine in DKD forward, a two-day consensus-building meeting was organized with different stakeholders involved in drug development and patient care in DKD, including patients, patient representatives, pharmaceutical industry, regulatory agencies representatives, health technology assessors, healthcare professionals, basic scientists, and clinical academic researchers. The study summarizes their views with regards to benefits and obstacles of implementing precision medicine in diabetic kidney disease (DKD) and discusses how to build consensus about a way forward to treat, prevent, or even reverse this disease.

Link to the paper:

Published in:
Frontiers in Pharmacology


5th BEAt-DKD annual plenary meeting

Scientists of the BEAt-DKD consortium and members of our strategic Advisory Board convened for the Annual Plenary meeting at the Nicolaus Hotel in Bari, Italy on 2-4 May 2022, with additional 30 scientists participating remotely. Five years into the project, work packages presented exciting new data and overall great progress. Next Plenary meeting will be organized in June 2023, by the academic lead Lund University, in Malmö. Sweden.

iBEAt protocol published


iBEAt protocol paper accepted in BMC Nephrology

iBEAt is a prospective multi-centre observational cohort study recruiting 500 patients with type 2 diabetes (T2D) and eGFR > 30ml/min/1.73m2. Being the largest DKD imaging study to date, iBEAt will provide invaluable insights into the progression and heterogeneity of DKD, and aims to contribute to a more personalized approach to the management of DKD in patients with type 2 diabetes.

Control podocytes

GSK3 knockout podocytes

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Preclinical studies show that the enzyme Glycogen Synthase Kinase 3 (GSK3) is a critical regulator of cellular function in podocytes and nephrocytes. Mechanistically GSK3 is important for maintaining the differentiated phenotype of these cells and preventing them from re-entering the cell cycle resulting in apoptosis through mitotic catastrophe.


New BEAt-DKD Newsletter

Highlights from the BAEt-DKD Symposium on Precision Medicine in Diabetic Kidney Disease.


Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

In this study it was shown for the first time that decreased expression of the renoprotective factor dicarbonyl and L-xylulose reductase (DCXR) is associated with human chronic kidney disease (CKD) progression. DCXR is mainly expressed in renal proximal tubuli and DCXR expression was also significantly reduced in CKD as compared to healthy controls. Due to its mechanistic link to the degradation of dicarbonyl compounds, DCXR depicts a novel target in CKD.


Multimarker Panels in Diabetic Kidney Disease: The Way to Improved Clinical Trial Design and Clinical Practice?

Diabetes Event

2nd Symposium on Precision Medicine in Diabetic Kidney Disease – Stakeholders´Perspectives: Amsterdam, Netherlands, 3-4 April 2019

The goal of this symposium is to reach a consensus on how to move Precision Medicine into daily clinical practice of treating diabetes. We think that this will only happen if we can align stakeholder opinions and goals. Therefore, this symposium invites stakeholders from patient organizations, physician groups, drug regulators, health technology assessors, academia, and industry to participate in brainstorming and discussion. This meeting is part of WP6, the IMI2 BEAT-DKD project.

For more information on the symposium:

Diabetes Event

2nd BEAt-DKD annual plenary meeting

More than 80 scientists of the BEAt-DKD consortium and members of our strategic Advisory Board convened for the Annual Plenary meeting at the Biomedicum in Helsinki, Finland on 15-16 October 2018. Two years into the project, work packages presented exciting new data and overall great progress. Next Plenary meeting will be organized on 15-16 October 2019, by the academic co-lead University Medical Center Groningen, the Netherlands.

Diabetes Event

Supplement of the journal Diabetes, Obesity & Metabolism

BEAt-DKD aims to foster personalized medicine for diabetic kidney disease. Personalized pharmacotherapy requires an integrated effort of many stakeholders including healthcare providers, the academic community, the pharmaceutical industry, trial designers, health policy makers, regulatory authorities, insurance companies, doctors, patients and the general public. Early engagement of these stakeholders is important as they may have different priorities. BEAt-DKD participants organized a conference on personalized medicine in diabetic kidney disease in December 2017 in Groningen, the Netherlands to discuss the state of the art, challenges and solutions for successful implementation of personalized medicine in diabetic kidney disease. A summary and main findings of this conference are now published in a dedicated supplement of the scientific journal Diabetes, Obesity & Metabolism.

Diabetes, Obesity & Metabolism, Volume 20, Issue S3.
Guest editor: Hiddo J. L. Heerspink


Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes


Paradigm shift in the diagnosis of diabetes

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Lancet Diabetes Endocrinol. 2018 Mar 1. pii: S2213-8587(18)30051-2.
DOI: 10.1016/S2213-8587(18)30051-2

News Picture

Results from BEAt-DKD research published in Nature Communications

BEAt DKD Meeting Picture

First BEAt-DKD Plenary meeting held in October 2017

One year after the start of BEAt-DKD on 1st September 2016, more than 60 scientists of the BEAt-DKD consortium convened for the first Plenum meeting in a pleasant and very positive atmosphere in Oberursel, Germany on 5-6 October 2017. During the assembly, kindly hosted by project co-leader Sanofi, the six project work packages presented already great progress and achievements for these first 12 months. The Plenary meeting also gave the opportunity for many of our researchers to meet in person for the first time and to explore joint research interests, while aligning our key research activities towards project year two.

We were very happy to welcome the members of our strategic Advisory Board, advising us on research strategies and focus points, which will further improve the smooth running and the achievement of future goals of the project.

Overall, the first annual meeting of the BEAt-DKD consortium, with a near complete representation from our 31 partners, resulted in a very fruitful meeting, leaving everyone feeling happy after 2 days of intensely working together towards the final goal of BEAt-DKD: to elucidate targetable mechanisms and pathways underlying the initiation and progression of DKD.

The second Plenary meeting will be organized by the academic co-lead University of Helsinki on 15-16 October 2018.

News Picture

Boehringer-Ingelheim joins the BEAt-DKD consortium as new participant

As 7th EFPIA partner, Boehringer-Ingelheim has joined BEAt-DKD on 13 Nov 2017 to bring their expertise in research on diabetic kidney disease (DKD) into the consortium. Their comprehensive knowledge in research and development of compounds for the treatment of diabetes and cardio-vascular diseases will support the overall project goal to elucidate targetable mechanisms and pathways underlying the initiation and progression of DKD. Analytical assays and pre-clinical models provided by Boehringer-Ingelheim will complement technologies already available in the consortium for the identification and validation of biomarkers of disease progression and treatment response as a first step towards precision medicine of DKD.

Press release news picture

Press Release

Biomarker Enterprise to Attack DKD (BEAt-DKD), a unique project of the Innovative Medicines Initiative 2 (IMI2) on precision medicine in Diabetes Kidney Disease (DKD) got started on 1st September 2016.